Effect of oral contraceptive on cardiac output in rats

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Oral contraceptive pills are widely used and are generally safe and effective for many women. The World Health Organization has developed a risk classification system to help physicians advise patients about the safety of oral contraceptive pills. The choice of pill formulation is influenced by clinical considerations. By choosing appropriately from the available pill formulations, family physicians can minimize negative side effects and maximize noncontraceptive benefits for their patients. Additional monitoring and follow-up are necessary in special populations, such as women over 35 years of age, smokers, perimenopausal women and adolescents. Third-generation progestins are additional options for achieving noncontraceptive benefits, but their use has raised new questions about thrombogenesis.
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Hormone levels in women using contraception affect nerve activity involved in vessel constriction

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Risks of contraception and pregnancy in heart disease

Sports Medicine. The female athlete, during her reproductive years, has a complex and ever-changing milieu of female steroid hormones, whether it is the endogenous variations in estradiol and progesterone of a regular menstrual cycle, or the exogenous synthetic hormones of the oral contraceptives. Both estrogens and progestins have individual, interactive and sometimes opposing physiological actions with potential implications for the exercising female. The best performances were generally in the immediate postmenstrual days, with the worse performances during the premenstrual interval and the first few days of menstrual flow. However, this type of study has an inherent built-in bias, and is further limited by the lack of substantiation of cycle phase. Many of the women studied associated premenstrual symptoms, such as fluid retention, weight gain, mood changes, and dysmenorrhoea with performance decrement. Such factors have also been causally linked with an increase in traumatic musculoskeletal injuries during the premenstrual and menstrual period.
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Risks of contraception and pregnancy in heart disease

Cardiologists need to be able to both advise women with heart disease of the risks of pregnancy and to give them the information they need to avoid unplanned pregnancies safely. There is a lack of published data about contraception for women with heart disease. In extreme examples women whose cardiac risk associated with pregnancy is low have been advised to undergo termination and sterilisation. For each contraceptive method the contraceptive efficacy and the cardiovascular risks should be considered.
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Response: The drug-induced long QT syndrome diLQTS is a problem for clinicians balancing risk and benefits across multiple therapeutic areas, and for pharmaceutical scientists and regulators evaluating new drug candidates. The prevalent view is that block of a specific ion current, the rapid component of the cardiac delayed rectifier IKr , is the common mechanism predisposing to diLQTS across drug classes and that patients with mutations in ion channel genes are at especially increased risk. In the very extreme form of diLQTS, a specific form of ventricular arrhythmia potentially lethal, called Torsade de Pointes, can occur. Women are at higher risk of diLQTS than men.
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